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HomeEuropean NewsTurning miracles of science into actuality for sufferers – POLITICO

Turning miracles of science into actuality for sufferers – POLITICO


Brendan O’Callaghan, Government Vice President for World Industrial Affairs at Sanofi

Brendan O’Callaghan is Government Vice President for World Industrial Affairs at Sanofi. He speaks about world manufacturing operations, supporting Sanofi’s more and more numerous pipeline, and taking a digital-first strategy to chasing the miracles of science that can assist rework the follow of medication for sufferers. 

Q. How would you clarify industrial affairs in a pharmaceutical firm?

A. We manufacture, provide and distribute medicines to sufferers all all over the world. We’ve a really massive community, with over 65 websites in 30 international locations supplying 140 international locations worldwide.  

When our analysis colleagues uncover a brand new medication, they develop an preliminary course of by which we are able to produce it. Our accountability is to then switch that know-how to our bigger scale manufacturing community. This permits us to launch the product, get it accredited by the regulatory authorities, after which develop the manufacturing capability to fulfill the demand for these therapies throughout the worldwide community we serve. 

Q. How did COVID-19 change your mindset or strategy to operations, and had been there particular adjustments significantly related for Europe?  

A. I feel COVID was a catalyst in revealing fragilities in Europe associated to pharmaceutical innovation and manufacturing capacities. We’ve discovered the significance of provide chain resilience and being able to withstanding shocks, to guard the well being and technical sovereignty of Europe as nicely.  

It is very important have a very sturdy well being infrastructure. The COVID-19 disaster prompted therapies to achieve sufferers in document time, with rolling evaluations and scientific dialogue demonstrating their worth in the course of the growth and registration of vaccines within the EU. Clearly throughout COVID, that was executed below conditions of maximum problem and disaster administration, and it confirmed that we are able to transfer at velocity and with no compromise on Security, High quality or Efficacy.  

What we’ve discovered is the significance of provide chain resilience to guard the well being and technical sovereignty of Europe.

Brendan O’Callaghan, Government Vice President for World Industrial Affairs at Sanofi

In case you take a look at COVID alone, clearly mRNA know-how was on the forefront in delivering a fast response. Loads of that discovery got here out of Europe, so it exhibits we’ve obtained the scientific innovation capacities right here.

Nonetheless, the problem for Europe is to leverage and construct on that scientific and innovation functionality.  There’s a chance to see how we are able to pull all of these constructing blocks collectively by way of well being care innovation extra broadly. I feel defining a long-term imaginative and prescient of the place Europe needs to steer goes to be vital to serving to us ship and join all of that ecosystem. If we can’t be profitable in leveraging that functionality to scale innovation, there’s a threat we’ll get left behind by way of scientific progress and higher serving public well being. 

Q. Sanofi lately made vital investments associated to its industrial community. In Europe, which investments are you most happy with? 

A. We’ve many issues to be happy with in Sanofi. We’re one of many largest pharmaceutical producers in Europe, with virtually two-thirds of our world footprint right here. We’ve over 40 manufacturing websites within the continent — 18 in France alone — which cowl all phases of manufacture: from the lively ingredient by to the ultimate dosage type. All of this functionality — throughout all know-how platforms — exists inside Sanofi at present, so we’re very happy with that. 

We’re repeatedly investing in our amenities, reaching over €1 billion a 12 months globally. However extra importantly, we’re investing for the longer term, to deliver the most recent in know-how and innovation to assist us be simpler and environment friendly. For instance, we’ve introduced that we are going to put money into two amenities we name EVF (Evolutive Vaccine Facility) — one in all which shall be situated in France and the opposite in Singapore. It’s setting a brand new commonplace for the manufacture of enormous molecules or biologics and vaccines, by way of enabling versatile manufacturing at scale and with velocity. These amenities will give us the flexibleness to modify from one product kind to a different throughout the similar facility, permitting us to fulfill the scientific wants popping out of our analysis labs and giving us the agility to reply with velocity to the wants of rising affected person populations.  

However, to reply your particular query, what I’m most happy with are the men and women who, on daily basis, work to find, develop and ship scientific miracles which assist sufferers in Europe and all around the world reside more healthy, higher and longer lives. 

Q. Our world is now predominantly digital-first. Might you inform us about your digital roadmap for industrial affairs at Sanofi?  

A. The accelerating data and understanding of biology is creating new alternatives for science and innovation in our labs. We see a shift in manufacturing. Slightly than amenities that provide medicines to very massive affected person populations, we’re shifting to an period of way more personalised approaches to well being care.  

We have to pivot to capabilities the place we are able to change rapidly from one product to a different. A part of our potential to try this shall be {our capability} to automate and digitize, to verify we’re capturing all the information we have to actually perceive our processes higher. They will subsequently develop into extra dependable and environment friendly, enabling even higher entry and attain to sufferers throughout the globe.  

For instance, we’ve lately introduced a partnership with McLaren, the place we’re leveraging know-how, knowledge and analytics to speed up our manufacturing efficiencies and construct actually world-class requirements of efficiency excellence right here at Group Sanofi. The Method One sector is targeted on innovation in a aggressive, high-performance, team-based surroundings the place the margins between success and failure are very small. We’re working with a group of oldsters from McLaren, leveraging their expertise and experience in precision engineering and superior analytics to seize the vital knowledge coming from our manufacturing gear. We then use that superior knowledge in machine studying and AI to assist us optimize the efficiency of our manufacturing strains. We’re constructing this partnership with one clear goal: to enhance our manufacturing efficiencies so we are able to speed up the attain of our medicines and vaccines to ever extra sufferers all over the world.

Q. A few 12 months in the past, Sanofi introduced its dedication to working in direction of a more healthy planet. What are your important targets and actions in that space?

A. All of us see the impacts of local weather change in entrance of us, and all of us perceive the sense of urgency to reply to that. At Sanofi, as a well being care firm centered on enhancing and increasing lives, we take extremely critically our accountability in making an attempt to attenuate the affect of our operations on the surroundings and the native communities the place we function.

Therefore we’re dedicated to being carbon-neutral throughout our operations by 2030 and to reaching web zero emissions by 2050. We intention to make all of our websites all over the world use 100% renewable electrical energy by 2030.

These are fairly formidable targets from the place we begin at present. We’re accelerating the mobilization of groups and dealing arduous with our know-how companions, to determine progressive applied sciences that may assist us progress in direction of our targets. I feel the present scenario in Europe, with the tragic circumstances in Ukraine, reinforce the precedence of local weather change, carbon neutrality and in the end being extra environment friendly in the usage of our scarce pure sources, significantly for vitality.  

In conclusion:

What will get us off the bed on daily basis is our alternative to have a optimistic affect on the well being and the lives of individuals all around the world.

Brendan O’Callaghan, Government Vice President for World Industrial Affairs at Sanofi

About Sanofi

We’re an progressive world well being care firm, pushed by one objective: we chase the miracles of science to enhance individuals’s lives. Our group, throughout some 100 international locations, is devoted to reworking the follow of medication by working to show the inconceivable into the attainable. We offer doubtlessly life-changing therapy choices and life-saving vaccine safety to thousands and thousands of individuals globally whereas placing sustainability and social accountability on the heart of our ambitions.

Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY



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